We Can Cure Ebola! (Mostly—Which Is Better Than Rarely) | SciShow News


[♩INTRO] More than eighteen hundred people have died
so far in the second largest Ebola outbreak in history. But doctors on the front lines now have a
new weapon. Two of them, actually, because a clinical
trial in the Democratic Republic of the Congo revealed
two new treatments which can cure the disease. The Ebola virus kills about three-quarters
of people who don’t receive medical care. And obviously, that’s a lot. But what’s really scary how many still die
with treatment. The standard treatment is a drug called ZMapp, but it only brings the average mortality rate
down to 49%. So in November of 2018, researchers started
a clinical trial to test several new drugs. One was an antiviral compound called Remdesivir, which is designed to gum up one of the main
proteins the virus needs to replicate. The other two attack the virus with antibodies: proteins made by the immune system which grab
onto potential pathogens so they can be destroyed. Antibodies can be very effective treatments if you can get them to stick. The trouble with Ebola is that it can change
shape and mask itself from the immune system, so it’s been hard to
find an antibody that always works. So, one biotech company used special animal
models to develop three different antibodies, which they then combined to make REGN-EB3
or just EB3. Other researchers looked for solutions in
living people. They managed to clone an antibody from someone who survived an Ebola outbreak in the 90s,
and called that mAb114. The trial compared these three new treatments
to ZMapp in nearly seven hundred patients over the
past nine or so months. And unfortunately, the antiviral didn’t
do much. The antibodies, though—they were amazing. A single dose of the lone antibody brought
mortality rates down to 34%, and one dose of the EB3 cocktail dropped them
all the way to 29%. But an even bigger win came for patients who
were treated with one of these within three days of getting sick — between
89-94% of them survived! That’s so effective that the researchers
decided to call off the trial right there so they could give everyone the potential
cures. Now, doctors will start a new trial with just
EB3 and mAb114 to see how they compare, and both drugs will be made available to people
who aren’t part of the research. And Ebola isn’t the only deadly disease
we’ve gotten closer to curing. Just last week, the US FDA approved a new
treatment for antibiotic-resistant tuberculosis a critical step towards getting the drugs
to where they’re needed most. Tuberculosis, or TB, is a bacterial lung infection. And we’ve had vaccines and antibiotics for
it for years now. But about ten million people around the world
still get TB, and one particular strain is resistant to
our usual treatment methods, making it extremely deadly. The vast majority of people who contract drug
resistant TB die before they’re even diagnosed, and even with treatment, only 34% of them
make it. Plus, that treatment involves taking upwards
of 40 pills a day for up to two years, and can have some serious side effects. Obviously, it’d be great if we had an easier,
more effective option. But developing new antibiotics is really expensive, and few companies are willing to make the
investment, especially when the majority of people with
TB are poor and can’t afford expensive drugs. Luckily, nonprofits like the TB Alliance have
stepped up. And it’s thanks to their influx of cash that the antibiotic which just won over the
FDA, called pretomanid, was developed. A clinical trial of the drug which began in
2015 found that, when pretomanid was combined with two
other antibiotics, almost 90% of people recovered in six months. And patients only have to take five pills
a day! That overwhelming success convinced the FDA
to approve of the three-drug regimen. And when the FDA approves of something, international organizations often follow suit. But there are still challenges ahead. Bacterial infections like TB are more common
in impoverished areas of the world, so antibiotics need to be priced in a way
that poorer patients can afford them. And even non-profits with the best intentions
can run out of money. So they need to get manufacturers to agree
to price the drug reasonably. Those negotiations are going on right now,
so let’s all keep our fingers crossed. Thanks for watching this episode of SciShow
News! But before you go, there’s one more thing
I’d like to mention. It’s not exactly news, but if you’re the
kind of person who likes to jazz up your jacket or backpack
with an awesome pin, you might want to head on over to DFTBA.com/scishow. Our August Pin of the Month, which features
the Curiosity rover, is only on sale for another week! And I know you don’t want to miss out on
such a stylish, adorable tribute. [♩OUTRO]

100 thoughts on “We Can Cure Ebola! (Mostly—Which Is Better Than Rarely) | SciShow News”

  1. And you know what? The reservoir population for Ebola is apparently bats, which noone tries to treat with anti-biotics or anything else, so the chances of Ebola developing resistance are close to zero.

    Too bad that one of the TB variants (there's apparently two, the other of which has cattle as it's reservoir), is humans.

  2. Has anyone ever tried natural solutions? Vitamin C and Garlic Oil really do work, I have tried them myself with various ailments. Haven't been to a doctor in 50 years so they must have value.

  3. Just goes to show that with a scared enough populace, the money and cures will eventually come for all transmittable diseases. The wealthy will happily cough up the money they avoid paying with broken tax laws to cure diseases they are worried about contracting not to mention the social prestige in a world where individuals now have more money and resources than most governments of countries.

  4. The policy seems to be:
    1) Cure the people of Africa of diseases so that they can live longer, breed and multiply.
    2) When an African country has too many people for the land to support, they ask for Aid.
    3) The West sends Aid but some Africans want more so they emigrate.
    4) On arrival in Western countries the Africans want everything except work.
    5) We keep them, feed them and house them – and wonder what´s gone wrong.

  5. Now, if only we could do the same thing for malaria. Generally we don't put a lot of money into researching diseases that mainly effect poor people – blessed are those NGOs who fund this research. I guess Ebola is scary enough that people are willing to put the effort in – I think it is a CYA thing because people are so scared of Ebola getting to the U.S. and mainland Europe. Malaria kills FAR more people than Ebola, but isn't likely to outbreak in the "developed" world since it can only be transmitted by specific mosquitos. So, I mean, who cares if more people die of malaria than by just about any other infectious cause….they are poor and far away.

  6. It has become fashionable to blame whites for testing drug trails on Africans.
    Will all the people with Ebola in Sweden please report to the pharma co who is …………………
    Oh by the way. Only white Swedes not migrants.

  7. oh but i thought they don't make cures on purpose because it's all a conspiracy 🙂
    No? Oh ok, what a surprise

  8. Why should drug companies work for free?
    Or even at cost of the ingredients/mfg process? What's really being said is that the US should give away thier technology. Where are the local governments and thier paychecks?
    Bankrupting the people who can create these cures sounds great and all because screw the greedy drug companies right? Until they won't make new drugs.

  9. As messed up as this sounds, this cure is a double-edged sword-it can be good to cure those that do need this but also, increase the chance of overpopulation; the world is getting overpopulated and this cure would prolong life in countries that do not need more people. As messed up as this sounds, death is a necessary element that controls our population, specially the poor that only procreates uncontrollably and risking the lives of their children in this harsh world.

  10. Man was Ebola really that bad? Just let it do it's thing. Nature is trying to help everyone out, why fight it? Why does the west have to stick it's big nose into other peoples business, just let it take it's course damn. Stop trying to save people who hate you.

  11. Aren't drugs like relatively cheap to mass produce? Its just the companies in america who get to decide how much they cost that makes them expensive there

  12. Remember when there was that huge outbreak, then the news got bored terrifying people, so it just disappeared? Kinda shows you the attention span of the American people.

  13. Is there some way people can donate to the effort to get the TB drug to market at a low price? Could a large sum of money get the pharmaceutical company to lower their price? If so, could someone like Gates. Zuckerberg, or the folks at Google simply save the lives of 10 million people? Or a million people each chip in fifty to get the job done?

  14. TIL corporations can clone parts of your body and sell them for profit.

    I hope "someone who survived an Ebola outbreak in the 90s" at least gets some form of recognition or better yet compensation.

  15. The fact that the researchers are getting the medicines out early bc they work so well makes me really happy. It shows that they truly care.

  16. It takes years to find a suitable antibiotic that is effective at treating a wide range of illness (regardless of what you think or how you feel these are the only types which will ever make it) on top of that you need 10 years worth of double blind testing. After all this you hope and pray it's effective or the virus doesn't mutate and you are left with a antibiotic which costs a company 100's of millions and 10 years of active work, than if all this goes well you have to hope it doesn't cause any long term damage antibodies kill they don't care what they kill it could just as easily be us as a virus but we try and watch out for this kinda stuff.

    Some of the worlds most effective antibiotics are considered last line of defense/last resort due to their side effects but I mean if you are going to die without treatment you might as well try everything you can.

  17. There is a real cure and I suggest everybody see this interview by bulletproof Dave asprey about it called podcast #168 – Dr. Robert Rowen: Treating Ebola & ozone therapy.

  18. yeah, i saw the news about ebola cure on twitter last week (i think it was scientific american who posted it?),and i knew you would make a video on it, its such an important news!

  19. Honestly, after hearing how manufacturers try to milk something they didn't pay for to develop, I feel bursting with rage. That's so unbelievably unfair, it's just beyond comprehension. The most expensive part of developing a new drug is the R&D. In this case, someone gave the money altruistically, so that poor people don't have to die from this horrible disease. They developed the drug, they paid for the FDA approval (which if I remember correctly costed about 10M) and now that the drug is ready, some stupid greedy vultures want to cash in??? WTF is wrong with this world! I simply cannot understand it!

  20. With my luck in gachas, if the cure is a 99% success, then I will die. If it’s a 100% cure, then I will be the one that brings the success rate to 99%

  21. "companies dont want to invest in TB research because TB patient are poor and can't afford to pay a lot for medicine" is one of the most dystophian sentences I've heard all week

  22. Still desperately need an inactivated measles vaccin for those of us who cannot get boosters of what's available now.

  23. Just let every country let pay 10% of they military expanses into medical research. You will not miss the rusty tanks in 20 jears when you are gravely ill.

  24. Health and well-being is a matter of humans as a whole species, it's not about countries, races, being wealthy or poor, nor about Justice in tax paying, collection and distribution. No one knows where or when a disease would threaten the whole of our species, or other living creatures, resulting in a world catastrophe or even our extinction. Saving some hundreds or thousands of poor Africans means protection for mankind. There are a few issues, projects, our species need to solve and, or address for all, for good, beyond politics and economics: World Environment, food, health, well-being, Earth and space sciences, mainly space traveling and colonization of other worlds… though I really think we do not fit well and our extinction would do better to Earth and the whole universe…

  25. Economy is not natural Phenomeno. As anyone can keep doble accounting books, world economy can opt to put out of the troubles basket most of basic human needs… somebody said there's no problems, only solutions, but…some days later he was shoot dead…and who cares anyway…?

  26. Dont wanna sound dumb😭 but ebola changes shapes to hide from the immune system but so does aids. So why cant we cure that also

  27. This (the ebola piece) is absolutely terrible news.
    Why would we want to save poor 'people' who can't clean themselves and take a bit of advice about quarantine?

  28. Well… as a kid from the late 80s and early 90s this vanquishes the invincible super plague that was going to wipe out the world and that spawned a ton of movies. (Ebola outbreak in the 90s really did a number on the collective consciousness.) Huh. More or less, anyway. It used to be invincible, so like yeah that's a huge improvement.

  29. 》is a millionaire with a millionaire brother
    》talks about non-profits running out of money
    》plugs a useless pin that only fools will buy
    》does not use platform to plug said non-profits
    Hank Green everyone!

  30. Nature creates disease to balanace the economy and humans make cures lol there will me more plauges more dangerous than ever!

  31. Regarding Ebola Virus,
    Have you tried Boric Acid?
    Take a small amount of Boric Acid powder on your finger print once a day for a week should cure just about any virus.
    Boric Acid is also inexpensive.
    It works by killing the titers that cause the viruses.
    Antibiotics have no effect on viruses. Antibiotics are only used for treating bacteria not viruses.
    Boric Acid cures AIDS, Hepatitis, Epstein Barr Virus and leprosy.
    God bless you and your families.
    🌈😁Carol

  32. As someone who lives in the Philippines where TB is rampant, I appreciate SciShow covering the economic obstacles of fighting the disease. Good job, Hank!

  33. Fantastic video…again, Hank.
    Hank being an exception, as a species we truly do represent far too adeptly stupidity upon stupidity. We deny climate disaster as we deny ourselves treatment for diseases simply for lack of a self-made construct, money – currency having NO backing or true value, and at times worth even less than the paper it's printed on. Soooo we make our SELVES miserable while others die………now THAT is a back of the short bus window-licking self-destructive kinda stupid and I personally don't blame aliens for not stoppin' n stayin'.

  34. Doctors prescribe Boric Acid to babies with thrush mouth.
    It is strong enough to kill cockroaches and ants and yet it is gentle enough for babies.
    Boric Acid kills the microscopic parasites called titers that cause viruses.
    Again antibiotics are not effective for viruses. Antibiotics are only effective for treating bacterial infections. Boric Acid works only for viruses.
    God bless you and your family.

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